Mechanistic Target of Rapamycin Complex 2

A multiprotein complex consisting of mTOR KINASE; MLST8 PROTEIN; rapamycin-insensitive companion of mTOR protein (RICTOR PROTEIN); and PRR5 (proline-rich protein 5). Like mTORC1, it also regulates cell growth and proliferation in response to growth factors but may not be as sensitive to nutrient availability and is insensitive to SIROLIMUS. In contrast to mTORC1, it can regulate the ACTIN CYTOSKELETON through RHO GTPASES to promote the formation of STRESS FIBERS. The mTORC2 complex also plays a critical role in AKT1 PROTEIN KINASE phosphorylation and activation.

Also Known As:

MTORC-2; TOR Complex 2; TORC2; Target of Rapamycin Complex 2; mTORC2; Complex 2, TOR

Macromolecular Substances: 97
- Multiprotein Complexes: 125
  - Mechanistic Target of Rapamycin Complex 2: 777
Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Transferases: 6589
    - Phosphotransferases: 42769
      - Phosphotransferases (Alcohol Group Acceptor)
        Protein Kinases: 9677
        Protein Serine-Threonine Kinases: 3588
        TOR Serine-Threonine Kinases: 5978
        Mechanistic Target of Rapamycin Complex 2: 777
Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Intracellular Signaling Peptides and Proteins: 32
    - Protein Serine-Threonine Kinases: 3588
      - TOR Serine-Threonine Kinases: 5978
        Mechanistic Target of Rapamycin Complex 2: 777

Seong-il Lee Selected Research

Seong-il Lee Research Topics

Disease

Drug/Important Bio-Agent (IBA)